36 articles - From Friday Aug 16 2024 to Friday Aug 23 2024
Guidelines and related publications, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
| Aliment Pharmacol Ther |
|---|
Systematic review: Mortality associated with raised faecal immunochemical test and positive faecal occult blood results. All-cause, non-CRC and cause-specific mortality appear higher in those with raised f-Hb. Population-based studies are warranted to elicit whether this association occurs in symptomatic patients. |
| Clin Gastroenterol Hepatol |
Symptom profile of patients with intestinal methanogen overgrowth: A systematic review and meta-analysis. Patients with IMO exhibit a higher rate and severity of constipation along with lower rate and severity of diarrhea. The distinct phenotype of IMO patients should be incorporated in patient-reported outcome measures and further correlated with mechanistic microbiome studies. |
| Gut |
Clinical outcomes of potential coeliac disease: a systematic review and meta-analysis. Almost a third of patients with PCD develop villous atrophy over time, whereas a similar proportion experience normalisation of serology despite a gluten-containing diet. Most symptomatic patients benefit from a GFD. These findings highlight the importance of structured follow-up and individualised management for patients with PCD. |
RCT, clinical trials, retrospective studies, etc…
| Am J Gastroenterol |
|---|
Acceptance & Commitment Therapy for Adults Living With Inflammatory Bowel Disease & Distress: A Randomized Controlled Trial. Both programs were of benefit to people with IBD and distress. However, ACT offers a significant added benefit for HRQoL and self-reported Crohn's disease activity and may be a useful adjuvant therapy in integrated IBD care. |
FECAL IMMUNOCHEMICAL TEST TO DETECT COLORECTAL NEOPLASIA IN LYNCH SYNDROME - A PROSPECTIVE MULTICENTER STUDY. FIT at thresholds ≤ 4.1 μg Hb/g feces may be a promising strategy to postpone colonoscopy in approximately 9 out of 10 individuals with Lynch syndrome. Large validation studies that also provide gene variant-specific outcomes should be prioritized. |
Granulocyte colony stimulating factor improves Prednisolone responsiveness and 90-day survival in steroid eligible severe Alcohol associated Hepatitis: The GPreAH Study a randomized trial. Addition of GCSF to prednisolone improves steroid responsiveness and 90-day survival with fewer infections and new onset complications in SAH patients. |
Oral breathing facilitates endoscopic operability compared to nasal breathing in peroral endoscopy: a randomized controlled trial. OB facilitates endoscopic operability compared to NB in peroral endoscopy. UE with OB is recommended as the preferred choice for unsedated peroral endoscopy in daily practice. |
PHYSIOLOGICAL AND PSYCHOLOGICAL FACTORS CONTRIBUTE TO REAL-TIME ESOPHAGEAL SYMPTOM REPORTING IN REFRACTORY REFLUX PATIENTS. Interpretation Real-time reflux symptom reporting is a multifactorial process, with both psychological and physiological processes contributing to different aspects of the reflux disease experience. Findings build on questionnaire-based research to underscore the importance of including psychological processes in our understanding of esophageal symptom reporting. |
Severe Polypharmacy Increases Risk of Hospitalization Among Older Adults with IBD. Severe polypharmacy was initially present in more than 25% of older adults with IBD and increased to 34% within 4 years of index visit. Severe polypharmacy, as well as PIM utilization among those with polypharmacy, were also associated with an increased risk of hospitalization at one-year, highlighting the need for deprescribing efforts in this population. |
Spine and sacroiliac joint involvement in newly diagnosed inflammatory bowel disease patients - clinical and magnetic resonance imaging findings from a population-based cohort. One-in-six newly diagnosed IBD patients had MRI findings indicative of axSpA. As 40% of these patients were asymptomatic, this suggests that axSpA is underdiagnosed in early IBD. Multidisciplinary collaboration is essential to ensure early detection of axial inflammation and to enable optimal therapy preventing future structural damage and disability. |
| Gastroenterology |
Spatially resolved niche and tumor microenvironmental alterations in gastric cancer peritoneal metastases. Our study provides a comprehensive molecular characterization of GCPM and unveils key biological principles underlying transcoelomic metastasis. The identified predictive markers, therapeutic targets, and TME alterations offer potential avenues for targeted interventions and improved patient outcomes. |
| Gastrointest Endosc |
A Single-center Pilot Study on the Efficacy and Safety of Acetic Acid-enhanced Magnifying Endoscopy with Narrow-Band Imaging for Diagnosis of Colorectal Epithelial Neoplasms. For diagnosing colorectal lesions, an AA concentration of 4.5% in ANBI-ME was safe and effective. Its diagnostic performance was comparable to CV-ME, and future large-sample studies may confirm its potential as a reliable alternative endoscopic diagnostic method. |
Development and Validation of a Machine Learning-based, Point-of-Care Risk Calculator for Post-ERCP Pancreatitis and Prophylaxis Selection. This study demonstrates the feasibility and utility of a novel machine learning-based PEP risk estimation tool with high negative predictive value to aid in prophylaxis selection and identify patients at low risk who may not require extended post-procedure monitoring. |
Efficacy of Cold Piecemeal Endoscopic Mucosal Resection of Medium to Large Adenomas Compared to Sessile Serrated Lesions. C-EMR seems to be less effective for the resection of large adenomas when compared to medium adenomas or large SSLs. C-EMR is equally safe for al lesion size and histology. |
| Hepatology |
Optimizing thiopurine therapy in autoimmune hepatitis: A multi-center study on monitoring metabolite profiles and co-therapy with allopurinol. Maintaining CBR in AIH was associated with 6TGN ≥223 pmol/0.2 ml. For patients who fail to achieve CBR and therapeutic 6TGN levels despite thiopurine dose increase due to preferential 6MMP formation, co-medication of allopurinol alongside low-dose thiopurines represents an efficient alternative. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Clin Gastroenterol Hepatol |
|---|
Modern Advanced Therapies for Inflammatory Bowel Diseases: Practical Considerations and Positioning. In this review, we discuss practical use of these newer advanced therapies focusing on real-world effectiveness and safety data, dosing and monitoring considerations, as well as special situations for their use such as pregnancy, co-morbid immune-mediated disease, use in hospitalized patients with acute severe UC, and in the perioperative setting. We also propose our approach to positioning these therapies in clinical practice, relying on careful integration of the medication's comparative effectiveness and safety in the context of an individual patient's risk of disease- and treatment-related complications and preferences. |
The cost of IBD care - how to make it sustainable. Addressing the increasing financial burden of IBD requires a comprehensive approach that tackles disparities, enhances access to cost-effective therapeutics, and promotes collaborative efforts across healthcare systems. Embracing innovative strategies can pave the way for personalized, cost-effective care accessible to al individuals with IBD, ensuring better outcomes and sustainability. |
| Gastroenterology |
misc publications eg case reports, tools of the trade, images of the month, etc…
| Am J Gastroenterol |
|---|
| Endoscopy |
| Gastroenterology |
| Gut |
Letters to the editors and authors’ replies
| Gut |
|---|
| J Hepatol |